Currently a process is underway to negotiate a new international instrument on pandemic prevention, preparedness and response (PPPR). On 5-7 December 2022, the Intergovernmental Negotiating Body [INB] (constituted by WHO member states), will meet in Geneva, Switzerland to discuss the recently released ‘Conceptual Zero Draft of the New International Instrument on PPR’. This statement is a response to the proposed new instrument from INPUD on behalf of people who use drugs globally and is informed by recent community-led research on PPPR among our networks and communities, as well as research conducted by INPUD during the Covid-19 pandemic.